mus musculus model

After being mated to expand their number and associated with a cocktail of nonpathogenic bacteria to normalize their physiology and prime their immune system, rederived rodents were transferred to so-called barrier rooms for large-scale production. Gelareh Mazarei, Blair R. Leavitt, in Movement Disorders (Second Edition), 2015. 15566. Direct contact has been found to be the most efficient mode of horizontal transmission, specifically when traumatized epidermis or mucous membranes were exposed to infectious urine or saliva (Skinner and Knight, 1973, 1979). As vertebrates and mammals, mice develop diseases that naturally affect immune, endocrine, nervous, skeletal, digestive, and cardiovascular systems. House mouse (Mus musculus) the common mouse is one of the species of the genus Mus.Often, it is just called a mouse.It is a small rodent.In most parts of the world, they live close to humans. The RefSeq genome records for Mus musculus were annotated by the NCBI Eukaryotic Genome Annotation Pipeline, an automated pipeline that annotates genes, transcripts and proteins on draft and finished genome assemblies.This report presents statistics on the annotation products, the input data used in the pipeline and intermediate alignment results. Aside from the close resemblance of many complex physiologic systems to those of humans, what makes the mouse an even more attractive model organism is its ease of reproduction, relatively low cost, and short gestation period (Gama Sosa et al., 2012). Silver (1995), drawing on detailed genetic analysis, lists 8 true species in the Mus subgenus plus 4 morphologically and biochemically distinct Mus musculus subspecies that together form an M. musculus species group. In immunocompetent adult mice experimentally inoculated with virus, the host immune response results in a CD8+ T-cell-mediated disease involving multiple organs. Scientific Name: Mus musculus. According to the second attachment of the same article, the Mus musculus and Rattus norvegicus belong to the animal list used for scientific purposes. Mice are the most commonly used model organisms in research labs, as they have very similar physiologies to humans and therefore the impact of human diseases and drugs can be tested in mice and the findings applied to humans. The modeling of those disorders that occur naturally in humans but not in mice (such as neurodegenerative diseases and cystic fibrosis) has become possible through genetic and environmental manipulation of mice. Mus musculus genome: All of the genetic information contained in Mus musculus, ... those pieces could be reassembled to produce a serviceable model of the mouse genome. Copyright © 2021 Elsevier B.V. or its licensors or contributors. for genetic research. Mus musculus: Taxonomy navigation › Mus All lower taxonomy nodes (16) Common name i: Mouse: Synonym i-Other names i ›LK3 transgenic mice ›Mus musculus Linnaeus, 1758 ›Mus sp. The mouse genome was sequenced in 2002 and it was shown that almost every gene in the mouse genome had a human homolog. Moreover, all animals of a specific inbred strain are genetically identical or isogenic. Mus musculus pups are born blind and deaf with overall limited sensory-motor abilities; they are also incapable of feeding or thermoregulation. The rest of the animals cleared the infection after 6 months of viremia and 12 months of viruria. Mus musculus (the house mouse) probably has a world distribution more extensive than any mammal, apart from humans. This chapter deals with pure ultrasonic vocalizations (USVs), the main topic of this volume, and shows how ultrasounds of adult house mice (other species of mice will not be considered here) have been studied in the context of acoustic communication, as characteristics of mouse populations, and as expressions of emotional/motivational states as well as genetic disorders of the vocalizing animals. F. Bonhomme, ... A. Orth, in Encyclopedia of Genetics, 2001. Its commensalism with humans has insured its spreading all over the world, and probably oriented the choice of late 19th century biologists that have established it as the prime mammalian laboratory model. This model was created from micro-CT segmentation. Jump to: navigation, search. About one hundred years later, it ar… Random as well as directed mutagenesis is possible. The model can be used to make informed predictions regarding muscle function within a wide range of movements of the rodent hindlimb. For this reason, there is a great deal of literature on many aspects of its biology and more than 6000 reference could be retrieved for the last 40 years. In the wild mice, as other rodents, are important food source for many predators: cats, foxes, birds, snakes, etc. These similarities include embryology, metabolism, and physiology of major organ systems including the brain. Mus musculus, mouse ... CT26.WT was stably transduced with the retroviral vector LXSN that contains the lacZ gene encoding the model tumor associated antigen (TAA), beta-galactosidase (beta-gal) to obtain the lethal subclone CT26.CL25 (ATCC CRL-2639). The mouse shares numerous anatomical and physiological similarities with humans. We use cookies to help provide and enhance our service and tailor content and ads. Mus musculus is now seen as a polytypic species where three main branches have differentiated in isolation within the last 500,000 years, and have come to contact again on several occasions. - Mus musculus (house mouse) skull - 3D model by jpeter99 (@jpeter99) [b180a69] A variety of inbred strains are available. Mouse pups also produce abundant ultrasonic vocalizations (USVs), whistle-like sounds within the 30–90 kHz frequency range above the human hearing threshold of 20 kHz (Sales & Pye, 1974; Sales & Smith, 1978; Zippelius & Schleidt, 1956). It is also the species which has paid the largest tribute to modern science, because the historical laboratory strains (the old inbreds) stem from this species through the old tradition of fancy mice which were bred in Europe and Asia for their coat color. NCBI Mus musculus Updated Annotation Release 108.20200622. This occurred at least three times independently, giving rise to the now well recognized peripheral subspecies: M. m. domesticus stemmed westward from the near East (Fertile Crescent) toward Europe and the Mediterranean; M. m. musculus colonized almost all of the Palearctic from eastern Europe to China, starting at the northern slopes of the Himalayas; M. m. castaneus went eastward from India through southeast Asia. The House Mouse Mus musculus is now seen as a polytypic species where three main branches have differentiated in isolation within the past 500 000 years and have come to contact again on several occasions. For the past decade, genetic engineering has focused on improving techniques to develop mutant embryonic stem (ES) cells; knockout, knockin, and conditional strategies; N-ethyl-N-nitrosurea mutagenesis; gene trapping; and multiparental recombinant inbred lines for use in mapping and studies involving quantitative trait loci. Mus musculus is the experimental model organism that permits the most diverse strategies of assessing the role of specific genes and the phenotypic manifestation of genetic variation in mammals. Henry Foster, the veterinarian who founded Charles River Breeding Laboratories in 1948 and a pioneer in the large-scale production of laboratory rodents, stated in a seminar presented at the 30th anniversary of AALAS, “After a variety of frustrating health-related problems, it was decided that a major change in the company’s philosophy was required and an entirely different approach was essential”. For instance, they can produce vocalizations in the audible range when cleaned by the mother, in response to pain or rough-handling, or when accidentally pinched. Günter Ehret, in Handbook of Behavioral Neuroscience, 2018. Specific genes can be knocked out by homologous recombination. 2019-01-01 | S-EPMC6510792 | BioStudies scRNA-seq of Mus musculus subcutaneous Lin- cells derived from the subcutaneous adipose stromal vascular fraction The ability to manipulate the mouse genome using these techniques is a powerful tool for discovering relationships between genotype and phenotype, unveiling disease mechanisms, and developing therapeutics. Mus musculus is considered the primary reservoir for LCMV (Hankenson and Van Hoosier Jr., 2002). pcDNA3.1 + /C-(K)DYK or customized vector: 9-11: $223.30 $319.00: OMu41768: XM_006531442.3 Latest version! Mus musculus (mice) are considered to be useful model organisms for understanding and studying human disease. Young adult hamsters inoculated similarly developed viremia and viruria lasting 3 and 6 months, respectively, before clearing the virus (Parker et al., 1976). Its commensalism with humans has insured its spreading all over the world, and probably oriented the choice of late nineteenth-century biologists that have established it as the prime mammalian laboratory model. Search model organisms. A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. M. musculus is now seen as a polytypic species where three main branches have differentiated in isolation within the last 500 000 years, and have come to contact again on several occasions. Though human and mouse cohabitation can be traced back to the start of human civilization, domestication of mice as pets started in the 1700s by mouse fanciers in Japan and China. It is almost invariably considered as being constituted of three subspecies, Mus musculus castaneus being considered as more polymorphic, with a larger effective population size and as having retained more ancestral polymorphisms than the other two. The aim of study was to determine the effect of electric field, magnetic field, and infrared ray combination to lower insulin resistance in the type II diabetic model of Mus musculus. Mus musculus is the scientific name for a mouse. Mus mus­cu­lus may have orig­i­nally been dis­trib­uted from the Mediter­ranean re­gion to China, but it has now been spread through­out the world by hu­mans and lives as a human com­men­sal. Judy A. MacArthur Clark, Joanne Zurlo, in The Laboratory Mouse (Second Edition), 2012. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. 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Shek DVM, PhD, ... Kathleen R. Pritchett-Corning DVM, in, Laboratory Animal Medicine (Third Edition), Laws, Guidelines and Policies Governing the Use of Mice in Research, Judy A. MacArthur Clark, Joanne Zurlo, in. Since the House Mouse is often taken as a model species, this may have important bearings on our understanding of the context in which genome evolution and speciation occurs. After the rediscovery of Mendel’s laws in 1900, these colonies of ‘fancy’ mice – hybrids between Mus musculus domesticus and M. m. musculus – became the source of laboratory mice for early genetic studies. Have at least 8,000 years genome has some 3,000 million ( 3 billion ) base pairs and estimated! 223.30 $ 319.00: OMu41768: XM_006531442.3 Latest version been used to estimate mouse hindlimb muscle functions during locomotion. Method until random blood glucose level reached > 200 mg/dL Ehret, Reference! From approximately seven times the coverage of the house mouse ) probably has a distribution. 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